Single-use Chromatography Benchtop - 41 LPM
Engineered to optimize your bioprocess
Maximum flexibility
- Customize every aspect of the skid to meet your unique needs—whether it’s removing inlets/outlets, analytics, filters, columns, we can handle any combination of features/functions
- Column- and resin-agnostic—allows you to choose your preferred brand of columns/filters—whether Sartorius, Millipore, GE, Repligen, or a custom pre-filter
- Flexible automation based on ISA 88 Standards for batch operations: run manually, load individual steps (Prime, Wash, Load, Elution, etc.), or run a fully automated sequence
- Run process in upflow or downflow
- Transition from flow control to pressure control if needed (in case of filter fouling)
- Run, bind and elute, or flow-through process steps
- Add multiple column connections for serial operation, if needed
Optimized performance and fit
The chromatography skid is engineered to accommodate any low flow rate requirements. The result: column sizes and resin quantities can be optimized for the specific process needs, keeping raw material costs as low as possible. A broad dynamic range enables optimization of skid size for every application. And, the combination of optimally sized inline analytical sensors and well-less measurement devices reduce hold up.
Single-use technology for a safe and sterile process
- Fully sterilized, single-use tubing set, complete with integrated sensors, minimizes the risk of contamination
- Sterile-to-sterile connections for inlets/outlets reduce contamination risks
- Uses only the highest quality components, delivering USP <88> Class VI certified single-piece tubing sets that ensure sterility throughout use
- Flexible system design with configurable flow path - provides unmatched flexibility to meet your precise requirements
- Dual inlet headers with dedicated flow sensors - deliver accurate control throughout inline dilution and gradient steps
- Dual filter manifold - reduces risk of protein aggregation and eliminates the need for bubble traps
- Outlet back pressure control valve - enables offline column pressure simulation to stabilize pumps and smooth transition to inline columns
- State-of-the-art automation and control
| Attribute | C500 | C750 | C1000 |
|---|---|---|---|
| Tubing ID | 0.50 in | 0.75 in | 1.0 in |
| Flow Rates | 0.167-15 LPM | 0,167-20 LPM | 0.8-41 LPM |
| Pressure | 0-60 psi/4 bar | 0-60 psi/4 bar | 0-60 psi/4 bar |
| pH | 0-14 pH | 0-14 pH | 0-14 pH |
| Conductivity | 0-250 mS/cm | 0-250 mS/cm | 0-250 mS/cm |
| UV Wavelength | 0-2 AU Dual Wavelength-280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm | 0-2 AU Dual Wavelength-280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm | 0-2 AU Dual Wavelength-280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm |
| Temperature Range | 2-50°C | 2-50°C | 2-50°C |
| Humidity (non-condensing) | 10-90% | 10-90% | 10-90% |
| Utility Required, Skid Power* | 200-230 VAC | 200-230 VAC | 200-230 VAC |
| Wetted Materials | USP <88> Class VI and animal free | USP <88> Class VI and animal free | USP <88> Class VI and animal free |
| Inlets | 8 (4 ea inlet header) | 8 (4 ea inlet header) | 8 (4 ea inlet header) |
| Outlets | 2 | 2 | 2 |
| Flow Accuracy | ±3% | ±3% | ±3% |
| Hold-Up Volume-Inlet to Column | 1.33 L | 2 L | 3.5 L |
| Hold-Up Volume-Column to Outlet | .55 L | .75 L | 1.25 L |
| Dims (W x D x H)** | 910x910x1025 mm | 1622x1422x1816 mm | 1622x1422x1816 mm |
| Sensor Performance | |||
| Pressure | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) |
| Conductivity | 0-250 mS/cm (+0.25Ms/cm) | 0-250 mS/cm (+0.25Ms/cm) | 0-250 mS/cm (+0.25Ms/cm) |
| Flow | 0-20 LPM (± 3%) | 0-50 LPM (± 3%) | 0-100 LPM (± 3%) |
| pH | 0-14 pH (± 0.1) | 0-14 pH (± 0.1) | 0-14 pH (± 0.1) |
| UV | 0-2 AU (± 2%) | 0-2 AU (± 1%) | 0-2 AU (± 1%) |
Related Products
At Liquidyne, we prioritize our commitment to quality and consistency. In 2017 we achieved ISO 9001:2015 Quality Management System certification to ensure we can repeatedly deliver consistently high-quality products and solutions. Being an ISO 9001 facility, together with our USP Class VI Testing, ASME Bioprocessing Equipment (BPE), and EHEDG certification guarantee, we have the methodologies to assure quality. We will quickly and accurately rectify any issues if any of our products are ever in non-conformance.
"Thanks so much! What a quick turn around. It is a pleasure working with Liquidyne."
Process Development Manager
"I received the cart yesterday, thanks for the fast delivery! It feels sturdy. I sat on it. It does not bounce. It is also easy to clean and wipe or wash down."
Vice President, Analytical Development and Manufacturing
"Thanks again for reacting so quickly and meeting me halfway with the element. We will be able to get installed and have things keep moving overnight with the night crew. The little things like this are always greatly appreciated when working with Liquidyne."
Chemical Engineer
“This pump cut our processing time from 3 days to 1 shift. I’m not giving this pump back. You will have to come and get it if you want it... and that won’t likely happen.”
VP Antibody Manufacturing