Flexible Single-use TFF for Full-Scale Production - Up to 100 LPM
Designed to streamline your bioprocess, increase sample recovery and reduce the cost of consumables
A magnetically levitated pump combined with a cubical mixing bag with a magnetic mixer limits shear on the product throughout the filtration process, maximizing yield at every TFF step. The pump also maintains proper transmembrane pressure by providing a near pulsation-free fluid dynamic and meeting flow and pressure requirements; this is crucial to optimizing filter performance throughout the TFF process. Combined with an air-modulated diaphragm pressure control valve, retentate pressure reaches a set point almost instantly to achieve the desired TMP. These design features work to eliminate pump pulsations and pinching control valves that lead to more erratic pressure control.
Designed for temperature control of solutions from 2 – 50°C, you can run processes at higher concentrations and with more viscous solutions. The system also maximizes product recovery in the recirculation bag. Users simply disconnect the tubing from the TFF skid and move the recirculation bag to the next step for further processing. This results in fewer consumables and reduced costs while eliminating project delays due to supply chain issues with consumables.
Maximum flexibility
- Integrates virtually any brand hollow fiber and flat sheet style filters
- Custom single-use assembly accommodates Sartorius, Millipore, Pall, and other preferred filter brands
- Both recirculation vessel weight control and permeate flow control are available
- Diafiltration mode available (with buffer feed)
Single-use technology ensures a safe and sterile process
- Fully sterilized single-use tubing sets, complete with integrated sensors, minimize the risk of contamination
- Sterile-to-sterile connections for inlets/outlets reduce contamination risks
- Highest quality components; USP <88> Class VI certified single-piece tubing sets ensure sterility throughout use*
*Excludes flat sheet filter connections that are made at the time of use.
State-of-the-art automation and control—your way
We can deliver the TFF skid with your preferred automation and control system whether that’s DeltaV, Rockwell Automation, Inductive Automation Ignition Software, Wonderware, or other platforms. Our seasoned engineers have decades of experience across a wide range of platforms. Regardless of the platform you choose, the user experience is the same due to the ISA-88 batch-compliant structure that is used to create the building blocks of automation.
Easy-to-use, intuitive control panel
Our automation engineers have listened to end-users and applied years of bioprocess experience to optimize the user interface of the TFF system control panel. We have identified the functions and data that operators need to access most often, and the user interface brings these functions and data to the top layer of the screen—no more endless clicking or digging to access data.
- Low shear design maximizes yield
- Optimized TMP control streamlines your process
- Easily run processes with more viscous solutions
- Brand-agnostic design provides complete flexibility to integrate best-in-class components for every part of the skid
- Reduced cost of consumables
- State-of-the-art automation and control
| Attribute | T500 | T750 | T1000 |
|---|---|---|---|
| General Skid Specifications | |||
| Tubing Internal Diameter | Feed and Retentate: 0.50 in Permeate: 0.25 in Inlets: 0.25 in | Feed and retentate: 0.75 in Permeate: 0.5 in Inlets: 0.5 in | Feed and retentate tubing: 1 in Permeate: 0.75 in Inlets: 0.75 in |
| Tank Size | Up to 200L | Up to 650 L | Up to 1000 L |
| Feed Flow Rate | 0-10 LPM | 5 – 50 LPM | 10 – 100 LPM |
| Pressure rating | 60 psi/4 bar | 60 psi/4 bar | 60 psi/4 bar |
| Temperature Range | 2-50°C | 2 – 50°C | 2 – 50°C |
| Humidity (non-condensing) | 10-90% | 10 – 90% | 10 – 90% |
| Utility Requirements* Skid Power Mixer Power | 100-120 VAC | 220-230 VAC 100 – 120 VAC | 220-230 VAC 100 – 120 VAC |
| Wetted Materials | USP <88> Class VI and animal free | USP <88> Class VI and animal free | USP <88> Class VI and animal free |
| Membrane Holder Capacity | 0.5m2 to 5.0m2 | 0.5m2 to 5.0m2 | 2.5m2 to 10.0m2 |
| Feed and Filtrate Flow Measurement | Clamp on ultrasonic flow sensor (±3%) | Clamp on ultrasonic flow sensor (±3%) | Clamp on ultrasonic flow sensor (±3%) |
| Temp Control | 2-50°C | 2 – 50°C | 2 – 50°C |
| Inlets | 1 product 2 buffers | 1 product 2 buffers | To recirc bag: 3 inlets, 1 product, 2 buffers To feed pump: 3 inlets, 1 recirculating bag, 2 additional feed ports |
| Outlet Ports | 1 Filtrate | 1 Filtrate | Permeate: 2 outlets; waste or recycle Retentate; 3 outlets waste, recycle or recirculating bag |
| Minimum Working Volume Agitator Top Agitator Bottom Bag Sensors/Sampling | Depends on mixer selected | Based on 2OO L Bag 37 L 14 L 25 L | Based on 650 L Bag 82 L 31 L 55 L |
| Hold-Up Volume (excludes filtration device) | 750 mL | 1.5 L | 2.5 L |
| Dims (W x D x H)** Skid Bag Holder | 1219 x 787 x 1810 mm 1219 x 825 x 1595 mm | 1219 x 787 x 1810 mm 1219 x 825 x 1595 mm | 2032 x 1270 x 2108 1371 x 1066 x 1595 |
| Sensor Performance | |||
| Pressure | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) | 0 – 6 psi (± 2%) 6 – 30 psi (± 3%) 30 – 60 psi (± 5%) | 0 – 6 psi (± 2%) 6 – 30 psi (± 3%) 30 – 60 psi (± 5%) |
| Filtrate Conductivity | 0-250 mS/cm (±0.25 mS/cm) | 0-250 mS/cm (±0.25 mS/cm) | 0-250 mS/cm (± 0.25 mS/cm) |
| Vessel Weight | 0-200 kg (± 0.3%) | 0 -650 kg (± 3%) | 0-1000 kg (± 0.3%) |
| Flow | 0-10 LPM (± 3%) | 0-50 LPM (± 3%) | 0 – 100 LPM (± 3%) |
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At Liquidyne, we prioritize our commitment to quality and consistency. In 2017 we achieved ISO 9001:2015 Quality Management System certification to ensure we can repeatedly deliver consistently high-quality products and solutions. Being ISO 9001:2015 QMS Certified by Orion Registrar, Inc, together with our USP Class VI Testing, ASME Bioprocessing Equipment (BPE), and EHEDG certification guarantee, we have the methodologies to assure quality. We will quickly and accurately rectify any issues if any of our products are ever in non-conformance.
