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Agilitech Bio - Flexible Single-use TFF for Full-Scale Production - 100 LPM

Fit-for-purpose brand-agnostic design and open architecture ensures a system that meets your exact requirements.  Agilitech single-use tangential flow filtration (TFF) systems provide the flexibility and agility to perform purification operations upon delivery, while every part of the TFF system features best-in-class components to optimize performance.

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Flexible Single-use TFF for Full-Scale Production - Up to 100 LPM

Designed to streamline your bioprocess, increase sample recovery and reduce the cost of consumables

A magnetically levitated pump combined with a cubical mixing bag with a magnetic mixer limits shear on the product throughout the filtration process, maximizing yield at every TFF step. The pump also maintains proper transmembrane pressure by providing a near pulsation-free fluid dynamic and meeting flow and pressure requirements; this is crucial to optimizing filter performance throughout the TFF process. Combined with an air-modulated diaphragm pressure control valve, retentate pressure reaches a set point almost instantly to achieve the desired TMP. These design features work to eliminate pump pulsations and pinching control valves that lead to more erratic pressure control.

Designed for temperature control of solutions from 2 – 50°C, you can run processes at higher concentrations and with more viscous solutions. The system also maximizes product recovery in the recirculation bag. Users simply disconnect the tubing from the TFF skid and move the recirculation bag to the next step for further processing. This results in fewer consumables and reduced costs while eliminating project delays due to supply chain issues with consumables.

Maximum flexibility

  • Integrates virtually any brand hollow fiber and flat sheet style filters
  • Custom single-use assembly accommodates Sartorius, Millipore, Pall, and other preferred filter brands
  • Both recirculation vessel weight control and permeate flow control are available
  • Diafiltration mode available (with buffer feed)

Single-use technology ensures a safe and sterile process

  • Fully sterilized single-use tubing sets, complete with integrated sensors, minimize the risk of contamination
  • Sterile-to-sterile connections for inlets/outlets reduce contamination risks
  • Highest quality components; USP <88> Class VI certified single-piece tubing sets ensure sterility throughout use*

*Excludes flat sheet filter connections that are made at the time of use.

State-of-the-art automation and control—your way

We can deliver the TFF skid with your preferred automation and control system whether that’s DeltaV, Rockwell Automation, Inductive Automation Ignition Software, Wonderware, or other platforms. Our seasoned engineers have decades of experience across a wide range of platforms. Regardless of the platform you choose, the user experience is the same due to the ISA-88 batch-compliant structure that is used to create the building blocks of automation.

Easy-to-use, intuitive control panel

Our automation engineers have listened to end-users and applied years of bioprocess experience to optimize the user interface of the TFF system control panel. We have identified the functions and data that operators need to access most often, and the user interface brings these functions and data to the top layer of the screen—no more endless clicking or digging to access data.

  • Low shear design maximizes yield
  • Optimized TMP control streamlines your process
  • Easily run processes with more viscous solutions
  • Brand-agnostic design provides complete flexibility to integrate best-in-class components for every part of the skid
  • Reduced cost of consumables
  • State-of-the-art automation and control
AttributeT500T750T1000
General Skid Specifications   
Tubing Internal DiameterFeed and Retentate: 0.50 in
Permeate: 0.25 in
Inlets: 0.25 in
Feed and retentate: 0.75 in
Permeate: 0.5 in
Inlets: 0.5 in
Feed and retentate tubing: 1 in
Permeate: 0.75 in
Inlets: 0.75 in
Tank SizeUp to 200LUp to 650 LUp to 1000 L
Feed Flow Rate0-10 LPM5 – 50 LPM10 – 100 LPM
Pressure rating60 psi/4 bar60 psi/4 bar60 psi/4 bar
Temperature Range2-50°C2 – 50°C2 – 50°C
Humidity (non-condensing)10-90%10 – 90%10 – 90%
Utility Requirements*
Skid Power
Mixer Power
 
100-120 VAC
 
220-230 VAC
100 – 120 VAC
 
220-230 VAC
100 – 120 VAC
Wetted MaterialsUSP <88> Class VI and animal freeUSP <88> Class VI and animal freeUSP <88> Class VI and animal free
Membrane Holder Capacity0.5m2 to 5.0m20.5m2 to 5.0m22.5m2 to 10.0m2
Feed and Filtrate Flow MeasurementClamp on ultrasonic flow sensor (±3%)Clamp on ultrasonic flow sensor (±3%)Clamp on ultrasonic flow sensor (±3%)
Temp Control2-50°C2 – 50°C2 – 50°C
Inlets1 product
2 buffers
1 product
2 buffers
To recirc bag: 3 inlets, 1 product, 2 buffers
To feed pump: 3 inlets, 1 recirculating bag, 2 additional feed ports
Outlet Ports1 Filtrate1 FiltratePermeate: 2 outlets; waste or recycle
Retentate; 3 outlets waste, recycle or recirculating bag
Minimum Working Volume
Agitator Top
Agitator Bottom
Bag Sensors/Sampling
Depends on mixer selectedBased on 2OO L Bag
37 L
14 L
25 L
Based on 650 L Bag
82 L
31 L
55 L
Hold-Up Volume
(excludes filtration device)
750 mL1.5 L2.5 L
Dims (W x D x H)**
Skid Bag Holder
1219 x 787 x 1810 mm
1219 x 825 x 1595 mm
1219 x 787 x 1810 mm
1219 x 825 x 1595 mm
2032 x 1270 x 2108
1371 x 1066 x 1595
Sensor Performance   
Pressure0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
0 – 6 psi (± 2%)
6 – 30 psi (± 3%)
30 – 60 psi (± 5%)
0 – 6 psi (± 2%)
6 – 30 psi (± 3%)
30 – 60 psi (± 5%)
Filtrate Conductivity0-250 mS/cm (±0.25 mS/cm)0-250 mS/cm (±0.25 mS/cm)0-250 mS/cm (± 0.25 mS/cm)
Vessel Weight0-200 kg (± 0.3%)0 -650 kg (± 3%)0-1000 kg (± 0.3%)
Flow0-10 LPM (± 3%)0-50 LPM (± 3%)0 – 100 LPM (± 3%)

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